The Pet Oncologist - Vet Oncologist Online - Bladder & Prostate Cancer in Dogs (2024)

Transitional cell carcinoma (also called urothelial carcinoma) is the most common cancer of the urinary tract in dogs, that can affect the bladder and prostate. Diagnosis is usually confirmed with a biopsy (tissue sample) and sometimes cytology (fine-needle aspirate sample). However, biopsies and cytology may lead to seeding of cancer cells, where the cancer cells track along where the biopsy or needle tracts have entered in the body. The CadetBRAFtest is a non-invasive, highly sensitive and specific test that can detect urothelial carcinoma in dogs at an early stage, to help facilitate early intervention and treatment.

What is the CadetBRAFtest?

BRAFis a genetic mutation that is identified in around 80% of dogs with transitional cell carcinoma in the bladder and prostate. The CadetBRAFtest is PCR based genetic test that allows detection of this mutation in the urothelial cells that have been shed in the urine.

How accurate is this test?

This test can detect mutatedBRAFgene in as few as ten mutant-cancer bearing cells in a urine sample, so it can help detect early cases of urothelial carcinoma in dogs many months before clinical signs associated with the cancer becomes evident.

The sensitivity in detecting urothelial cancer in a dog with clinical signs is around 80%. The specificity of this test is >99.5%. All cases that have the presence of this mutation have had histopathologic confirmation of urothelial carcinoma. Normal dogs, dogs with benign polyps or inflammation of the urinary tract will not harbour theBRAFmutation. This means if the dog has a positive result, the dog has >99.5% chance that it most likely has urothelial carcinoma somewhere in the urinary tract. However, if the dog has a negative result, the dog can still have urothelial carcinoma, because around 20% of urothelial carcinomas do not possessBRAFmutation.

This test is not affected by the presence of blood, bacteria or protein in the urine.

When is theBRAFtest recommended?

  • Any dog with an unexplained abnormal bladder wall (e.g. bladder mass) or abnormal prostate gland on ultrasound examination.

  • Dogs with diagnostic imaging evidence of a bladder mass and clinical signs of lower urinary tract disease (e.g. haematuria, stranguria, dysuria and pollakiuria).

  • A screening test in high-risk breeds of dogs more than six years of age. High-risk breeds include Scottish terrier, Beagle, West Highland White terrier, Shetland Sheepdog, Jack/Parson Russell terrier, Fox terrier and American Eskimo Dog.

  • During chemotherapy to monitor treatment success by decreased levels ofBRAFmutation detection, or to monitor cancer relapse by re-occurrence ofBRAFmutation tumour bearing cells.

  • Early diagnosis in clinical cases with recurrent, complicated or antibiotic-resistant urinary tract infections presenting with haematuria without ultrasonographic evidence of a bladder mass.

What sample is required?

40 mL of free catch urine (not cystocentesis or catheterised urine) needs to be collected and placed immediately in a special preservative containingBRAFcontainer explicitly supplied by the laboratory. There are special instructions on how owners can collect this, but it is relatively straightforward. The urine sample can be collected over 2-3 days, and once the urine is the preservative solution, the sample is stable at room temperature for several days provided the sample is stored out of direct sunlight.

Is this test available in my country?

This test is readily available in the USA. However, it is also offered through other countries such as Australia, New Zealand, Hong Kong and Singapore. However, the sample will need to be shipped via FedEx to the USA, where this test is performed.

How long do the results take to return?

Once the sample arrives at the laboratory, the turnaround time is 3-6 business days. Shipping internationally to the USA via FedEx typically takes a few business days.

Vets, if you would like to know more about this CadetBRAFtest, please do not hesitate to get in touch by clicking here.

The Pet Oncologist - Vet Oncologist Online - Bladder & Prostate Cancer in Dogs (2024)

FAQs

How long can my dog live with prostate cancer? ›

As disease is often advanced once a diagnosis is made, survival time is very short. If no treatment is pursued, euthanasia is usually performed within a month of diagnosis. Depending on the treatment used, survival times average around 7 months after diagnosis.

How long will a dog live with a bladder tumor? ›

Survival is affected by the growth rate of the tumor, the exact location of the tumor within the bladder, and whether the tumor has spread to other organs or not. The median survival in dogs treated with chemotherapy or NSAIDs alone is 3-4 months.

How much does a BRAF test cost for dogs? ›

Cost. The exact cost of the Cadet BRAF test will vary depending on your location and the individual veterinary facility, but you should budget approximately $400.

What is the urine test for bladder cancer in dogs? ›

CADET® BRAF evaluates urine samples from dogs for the presence of cells containing a mutation for canine bladder/prostate cancer (TCC/UC). It's cutting-edge technology that is accurate, affordable, and convenient for both veterinarian and pet owner.

When should I euthanize my dog with prostate cancer? ›

It may be time to euthanize a dog with prostate cancer if he shows any of the following signs: Stops eating completely. Experiences continuous vomiting and diarrhea. Has trouble breathing (from metastatic disease)

What are the final stages of prostate cancer in dogs? ›

End Stages of Prostate Cancer

The end-stage disease of canine prostatic carcinoma is associated with abnormal urination, weight loss, and often signs associated with the cancer's metastasis. Signs of general decline, including lethargy, decreased appetite, and changes in demeanor, may also be seen.

Why do dogs get bladder tumors? ›

Bladder tumors in dogs have been linked to being overweight and to exposure to certain insecticides. It has also been proposed that chronic bladder infections and inflammation may increase the risk of developing bladder cancers.

Are bladder tumors in dogs always cancerous? ›

Bladder tumors are usually malaignant with only 3% of tumors being benign. Malignant tumors: transitional cell carcinoma is most commonly diagnosed, however other reported tumor types include squamous cell carcinoma, adenocarcinoma, fibrosarcoma, leiomyosarcoma and hemangiosarcoma, botryoid rhabdomyosarcoma.

Can a tumor be removed from a dogs bladder? ›

Surgery: If the cancer is in the apex of the bladder, surgery can be performed to remove the mass and attempt to obtain clean margins. However, even if margins are determined to be clean, tumors can recur or metastasize in about a year.

What is the new treatment for BRAF? ›

The Food and Drug Administration (FDA) recently approved the combination of the targeted drugs dabrafenib (Tafinlar) and trametinib (Mekinist) for the treatment of people with nearly any type of advanced solid tumor that has a specific mutation in a gene called BRAF.

Is it better to have BRAF positive or negative? ›

We have demonstrated that BRAF positive patients receiving targeted treatment have significantly better survival than their BRAF negative counterparts.

How accurate is the BRAF test for dogs? ›

The sensitivity is 85% (meaning that 15% of cancer cases will be missed) and the specificity is over 99% (meaning that less than 1% of cases will be wrongly diagnosed with the tumour). The test is not affected by blood or bacteria in the urine.

Are dogs in pain with bladder cancer? ›

Dogs that are suffering from bladder cancer will be in pain and will exhibit signs of having difficulty urinating. Depending on the stage of the cancer, a blockage may have formed in the bladder causing all functions of the bladder to cease.

What is the new test for bladder cancer? ›

Cxbladder provides greater confidence, reducing the need for further invasive procedures. Cxbladder Detect is a test designed to rule out urothelial bladder cancer in those experiencing blood in urine (hematuria).

How bad is bladder cancer in dogs? ›

Survival is affected by the growth rate of the tumor, the exact location of the tumor within the bladder, and whether the tumor has spread to other organs or not. The median (“average”) survival in 55 dogs treated with surgery alone (before drugs that could help were identified) was 109 days.

How long can a dog live with untreated prostate cancer? ›

If you decide not to treat your dog for prostate cancer, his life expectancy may only be a few months.

Are dogs with prostate cancer in pain? ›

Pets may strain to urinate or defecate, and the stools may become flattened or ribbonlike. Other signs may include lethargy, exercise intolerance, reduced appetite, weight loss, and pain (especially along the back or abdomen).

Is prostate cancer in dogs fatal? ›

Prognosis for prostate cancer is usually poor, and many dogs have metastases of the tumor to other organs by the time of diagnosis. Extensive monitoring during recovery is required. Even with aggressive treatment, life expectancy is often less than a year, making euthanasia a common consideration.

Does prostate cancer in dogs cause pain? ›

Prostate cancer is uncommon in dogs but sadly, when it does occur it tends to be aggressive, fast-growing, and very quick to spread around the body. Prostate cancer tends to cause problems with weeing and pooing, blood in the urine, abdominal (tummy) pain, and back pain.

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